Refinement of the pilocarpine-induced status epilepticus model in mice to improve mortality outcomes
Systemic pilocarpine administration has been widely implemented to generate rodent models of mesial temporal lobe epilepsy (mTLE), but pilocarpine-induced status epilepticus (SE) in mice causes a high mortality rate, likely due to cardiorespiratory collapse associated with prolonged seizures.Although it has been well known that SE impairs the funct